Morpholine → HCID 68139153, compound

HRID 1288171Notes

Reaction equation

HRID 1288171 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:20][CH2:19][C:18]2[C:9](=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]=2[CH3:21])[CH:8]([Cl:22])[CH2:7]1)=[O:5])[CH3:2].[NH:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>>[ClH:22].[ClH:22].[CH2:1]([O:3][C:4]([N:6]1[CH2:20][CH2:19][C:18]2[C:9](=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]=2[CH3:21])[CH:8]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 54025343HCID 54025343, compound

Product 1

HCID 68139153HCID 68139153, compoundYield 51%

Procedure

5-Morpholino-1,2,4,5-tetrahydro-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester dihydrochloride was prepared from 5-chloro-1,2,4,5-tetrahydro-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester and morpholine analogous to Example 173, but at atmospheric pressure.

Sources & evidence

ORD record
ord-0d2962abcce44b2da5bede513929f417
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

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