Hexanoyl chloride → 3-Caproyl-1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline

HRID 1288174Notes

Reaction equation

HRID 1288174 reaction equation
[CH3:1][C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=[C:4]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16][C:3]=12.[C:17](Cl)(=[O:23])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]>N1C=CC=CC=1>[C:17]([N:14]1[CH2:15][CH2:16][C:3]2[C:4](=[N:5][C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=3[C:2]=2[CH3:1])[CH2:12][CH2:13]1)(=[O:23])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

Participants

4

Reactant 2

HCID 67340Hexanoyl chlorideHCID 304399911-methyl-2,3,4,5-tetrahydro-1H-azepino[4,5-b]quinoline

Product 1

HCID 215033843-Caproyl-1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinolineYield 82%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3-Caproyl-1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline was prepared by acylation of 1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline with caproyl chloride in pyridine.

Sources & evidence

ORD record
ord-9ecfe9f1437a4bc0a9586a3b7b975656
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

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