Pyridine → HCID 21503420, compound

HRID 1288178Notes

Reaction equation

HRID 1288178 reaction equation
[CH3:1][C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=[C:4]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16][C:3]=12.[C:17]1(C)[C:18]([S:23]([Cl:26])(=[O:25])=[O:24])=[CH:19][CH:20]=[CH:21][CH:22]=1.N1C=CC=C[CH:29]=1>>[ClH:26].[C:21]1([CH3:29])[CH:22]=[CH:17][C:18]([S:23]([N:14]2[CH2:15][CH2:16][C:3]3[C:4](=[N:5][C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=4[C:2]=3[CH3:1])[CH2:12][CH2:13]2)(=[O:24])=[O:25])=[CH:19][CH:20]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 8623o-Toluenesulfonyl chlorideHCID 304399911-methyl-2,3,4,5-tetrahydro-1H-azepino[4,5-b]quinoline

Product 1

HCID 21503420HCID 21503420, compoundYield 50%

Procedure

3-p-Toluenesulfonyl-1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline hydrochloride was prepared by acylation of 1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline with -toluenesulfonyl chloride in pyridine.

Sources & evidence

ORD record
ord-a87fe707c7f14258977569eb8e940d6d
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

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