11-methyl-2,3,4,5-tetrahydro-1H-azepino[4,5-b]quinoline → 3-(p-Chloro-benzene sulfonyl)-1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline

HRID 1288179Notes

Reaction equation

HRID 1288179 reaction equation
[CH3:1][C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=[C:4]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16][C:3]=12.[S:17](Cl)([OH:20])(=O)=[O:18].[Cl:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>N1C=CC=CC=1>[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([S:17]([N:14]2[CH2:15][CH2:16][C:3]3[C:4](=[N:5][C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=4[C:2]=3[CH3:1])[CH2:12][CH2:13]2)(=[O:20])=[O:18])=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 304399911-methyl-2,3,4,5-tetrahydro-1H-azepino[4,5-b]quinolineHCID 21952870Chlorobenzene sulfochloride

Product 1

HCID 215035053-(p-Chloro-benzene sulfonyl)-1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinolineYield 75%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3-(p-Chloro-benzene sulfonyl)-1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline was prepared by acylation of 1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline with 4-chlorobenzene sulfochloride in pyridine.

Sources & evidence

ORD record
ord-ad61ab00bc1f4eb3af86895485d67a4c
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

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