Ethyl chloroformate → HCID 68139527, compound

HRID 1288186Notes

Reaction equation

[CH3:1][C:2]1[C:11]2[CH:10]=[C:9]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:7][C:6]=2[N:5]=[C:4]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20][C:3]=12.[Cl:21][C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[ClH:21].[CH2:25]([O:24][C:22]([N:18]1[CH2:19][CH2:20][C:3]2[C:4](=[N:5][C:6]3[CH:7]=[CH:8][C:9]([C:12]([F:14])([F:13])[F:15])=[CH:10][C:11]=3[C:2]=2[CH3:1])[CH2:16][CH2:17]1)=[O:23])[CH3:26]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 21503413HCID 21503413, compound

Product 1

HCID 68139527HCID 68139527, compoundYield 90%

Procedure

1,2,4,5-Tetrahydro-11-methyl-9-trifluoromethyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester hydrochloride was prepared from 1,2,4,5-tetrahydro-11-methyl-9-trifluoromethyl-3H-azepino[4,5-b]quinoline and ethyl chloroformate analogous to Example 155.

Sources & evidence

ORD record: ord-e1d9889f10114188b232231d6b83837f
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03987047

Reaction notes

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