Ethyl chloroformate → HCID 68140504, compound

HRID 1288194Notes

Reaction equation

C([N:8]1[CH2:22][CH2:21][C:20]2[C:11](=[N:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=3[C:19]=2[O:23][CH2:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[Cl:32][C:33]([O:35][CH2:36][CH3:37])=[O:34]>>[ClH:32].[CH2:36]([O:35][C:33]([N:8]1[CH2:22][CH2:21][C:20]2[C:11](=[N:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=3[C:19]=2[O:23][CH2:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:10][CH2:9]1)=[O:34])[CH3:37]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 21503451HCID 21503451, compound

Product 1

HCID 68140504HCID 68140504, compoundYield 51%

Procedure

11-[β-Phenyl-ethyl]oxy-1,2,4,5-tetrahydro-3-azepino[4,5-b] quinoline-carboxylic acid ethyl ester hydrochloride was prepared from 3-benzyl-11-[β-phenyl-ethyl]oxy-1,2,4,5-tetrahydro -3H-azepino[4,5-b]quinoline and ethyl chloroformate analogous to Example 208. Yield: 51% of theory; m.p. 153° C.

Sources & evidence

ORD record: ord-7502be64d40147079e192630f21752c7
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03987047

Reaction notes

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