Phenacylamine → HCID 53845549, compound

Participants

Reaction Steps

2,3,4,5-tetrahydro-11-methyl-1H-2-azepino[4,3-b]quinoline-carboxylic acid ethyl ester and their hydrochlorides were prepared from an isomer mixture of 1-ethoxycarbonyl-4-ethoxy-2,3,6,7-tetrahydro-azepine and 1-ethoxycarbonyl-4-ethoxy-5H-1,2,6,7tetrahydro-azepine (ratio: 1:1) and 2-amino-acetophenone analogous to Example 217. Yield of the dihydrochloride of the [4,5-b]-isomer: 52% of theory; m.p. 247° C. Yield of the dihydrochloride of the [4,3-b]-isomer: 43% of theory; m.p. 219° C.

Provenance & Evidence