反应详情

2-Phenoxypropylamine (6.0 g.) was added to a suspension of phenylacetamidine p-toluenesulphonate (12.4 g.) in absolute ethanol (20 ml.). The mixture was heated to reflux for 4 hours by which time the initially vigorous evolution of ammonia had practically ceased. The resulting solution was cooled somewhat and diluted with ether to give an oil which rapidly crystallised on scratching. The solid was filtered and recrystallised from a mixture of ethanol and water to give N-(2-phenoxypropyl)phenylacetamidine p-toluenesulphonate, m.p. 127°-129°.

1. temperatureThe mixture was heated
2. temperatureThe resulting solution was cooled somewhat
3. customto give an oil which
4. customrapidly crystallised
5. filtrationThe solid was filtered
6. customrecrystallised from a mixture of ethanol and water