Water → HCID 178427642, compound

Participants

Reaction Steps

The reaction between methyl 4-chlorophenyl(thioacetimidate)hydriodide (3.7 g.) and 2-3'-methylphenoxypropylamine (1.7 g.) was carried out as in Example 78, except that the reaction solution was diluted, not with ether, but with 2N-aqueous sodium p-toluenesulphonate (5.5 ml.) followed by water. The resulting crystalline product was recrystallised from a mixture of ethanol and ether, and then from a mixture of acetone and water, to give N-(2-3'-methylphenoxypropyl)-4-chlorophenylacetamidine p-toluenesulphonate, m.p. 145°-147°, undepressed on admixture with the product of Example 29.

Provenance & Evidence