反应详情

2-Phenoxypropylamine (4.6 g.) was added to a mixture of phenylacetyl chloride (4.6 g.) and anhydrous sodium carbonate (3.3 g.) in dry benzene (20 ml.); there was an exothermic reaction and effervescence. The mixture was heated to reflux for 1 hour, cooled, treated with water, and then shaken. The benzene layer was separated, dried over anhydrous sodium sulphate, filtered, and diluted with light petroleum (b.p. 60°-80°) to give pure N-(2-phenoxypropyl) phenylacetamide, m.p. 94°-96°.

1. customan exothermic reaction and effervescence
2. temperatureThe mixture was heated
3. temperatureto reflux for 1 hour
4. temperaturecooled
5. customThe benzene layer was separated
6. dry with materialdried over anhydrous sodium sulphate
7. filtrationfiltered
8. additiondiluted with light petroleum (b.p. 60°-80°)