HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Benzyloxyphenylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 1-(Benzyloxy)-3-(chloromethyl)benzene | HCID 13173490 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-Benzyloxyphenylacetonitrile | HCID 519831 | — |
Reaction Steps
A solution of sodium cyanide (5.9 g.) in dimethyl sulphoxide (40 ml.) was treated with 3-benzyloxybenzyl chloride (23.2 g.) and the reaction mixture stirred and maintained at 60° for 1 hour. The mixture was poured into water and the product was isolated with ether in the usual manner to give 3-benzyloxyphenylacetonitrile, b.p. 162°-166°/0.55 mm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03987158 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-d80b44e9bbcd4bf387415ded71bea0c3 |
| Source note | uspto-grants-1976_10 |