Sodium Dithionite → HCID 136138663, compound

HRID 1288260Notes

Reaction equation

HRID 1288260 reaction equation
S(S([O-])=O)([O-])=O.[Na+].[Na+].[NH2:9][C:10]1[N:11]=[C:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[O:25][CH3:26])[NH:13][C:14](=[O:18])[C:15]=1[N:16]=O>O>[NH2:9][C:10]1[N:11]=[C:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[O:25][CH3:26])[NH:13][C:14](=[O:18])[C:15]=1[NH2:16]

Participants

4

Reactant 2

HCID 24489Sodium DithioniteHCID 136354614HCID 136354614, compound

Product 1

HCID 136138663HCID 136138663, compoundYield 43.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium dithionite (8.7 g.) was added slowly to a stirred mixture of 4-amino-2-(2-methoxyphenyl)-5-nitrosopyrimid-6-one (6.15 g.) and water (90 ml.) at 70°-80° C., and stirring at that temperature was continued for a further 50 minutes. The mixture was then cooled, the yellow solid was filtered off, washed with water and dried to give 4,5-diamino-2-(2-methoxyphenyl)pyrimid-6-one (2.54 g.), m.p. 222°-223° C. (with decomposition), pure enough for use as a starting material in the next stage of the synthesis. Recrystallisation of a sample from ethanol gave analytically pure 4,5-diamino-2-(2-methoxyphenyl)pyrimid-6-one, m.p. 223°-224° C. (with decomposition).

Workup

  1. temperatureThe mixture was then cooled
  2. filtrationthe yellow solid was filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-43ea84a501d74bedb3aba2fdb45f9393
Source dataset
uspto-grants-1976_10
Patent number
US03987160

Reaction notes

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