反应详情

Sodium dithionite (8.7 g.) was added slowly to a stirred mixture of 4-amino-2-(2-methoxyphenyl)-5-nitrosopyrimid-6-one (6.15 g.) and water (90 ml.) at 70°-80° C., and stirring at that temperature was continued for a further 50 minutes. The mixture was then cooled, the yellow solid was filtered off, washed with water and dried to give 4,5-diamino-2-(2-methoxyphenyl)pyrimid-6-one (2.54 g.), m.p. 222°-223° C. (with decomposition), pure enough for use as a starting material in the next stage of the synthesis. Recrystallisation of a sample from ethanol gave analytically pure 4,5-diamino-2-(2-methoxyphenyl)pyrimid-6-one, m.p. 223°-224° C. (with decomposition).

1. temperatureThe mixture was then cooled
2. filtrationthe yellow solid was filtered off
3. washwashed with water
4. customdried