HCID 21504499, compound → HCID 131710506, compound

Participants

Reaction Steps

A solution of 2-(2-methoxy-5-nitrophenyl)-8-azapurin-6-one (1.87 g.) (prepared as described in Example 2) in 2-ethoxyethanol (50 ml.) was shaken at room temperature with a platinum oxide catalyst (0.12 g.) under hydrogen (5 kg/cm2). After the uptake of hydrogen was complete, the filtered solution was concentrated to dryness and the brown residual solid was recrystallised from aqueous N,N-dimethylformamide. A portion of this material was further purified by dissolution in 2N ammonium hydroxide solution followed by acidification of the filtered solution with 2N acetic acid. The brown precipitate was filtered, washed well with water and dried to give 2-(5-amino-2-methoxyphenyl)-8-azapurin-6-one hemihydrate (0.2 g.) in the form of a brown solid, m.p. 204°-206° C. (with decomposition, sintering at about 175° C.).

Provenance & Evidence