HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 19424196, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1H-Indole-3-carboxylic acid, 2-chloro-1-methyl- | HCID 99522 | — |
| Reactant | Glycine methyl ester hydrochloride | HCID 122755 | — |
| Product | HCID 19424196 | HCID 19424196 | 78% |
Reaction Steps
Similar reaction of 2-chloro-1-methylindole-3-carboxylic acid [XXI] with SOCl2 and glycine methyl ester hydrochloride gave N-carbomethoxymethyl 2-chloro-1-methylindole-3-carboxamide [XXII: R6 =H, R7 =CH2COOMe] (78% yield); mp (CHCl3 /light petroleum) 102.5°-104° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05464861 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-c2a0c5039c244ed2939ad3df71eecf53 |
| Source note | uspto-grants-1995_11 |