Aniline → HCID 136354621, compound

Participants

Reaction Steps

To a solution of 4-amino-2-butylpyrimid-6-one (7.65 g.) and sodium hydroxide (3.7 g.) in water (115 ml.) was added, at below 5° C, benzene diazonium chloride solution prepared (by the method well known in the art) from aniline (4.64 ml.), and the mixture was then heated to reflux for 1 hour. The pH was adjusted to 6 by the addition of aqueous sodium hydroxide solution, the product was filtered off, washed with water, dried and recrystallised from ethanol to give 4-amino-2-n-butyl-5-phenylazopyrimid-6-one (2.52 g.), m.p. 266°-270° C, pure enough for use in the next stage of the preparation.

Provenance & Evidence