反应详情

温度

82.5 °C

(Tetrahydro-pyran-4-yl)-hydrazine hydrochloride (1.975 g, 12.94 mmol), ethyl (ethoxymethylene)-cyanoacetate (1.958 g, 11.57 mmol) and sodium acetate (1.370 g; 16.70 mmol) were combined in ethanol (16 mL). The mixture was heated at 80-85° C. for 17 hours. After cooling to room temperature, the reaction was concentrated and the residue was partitioned between methylene chloride and water. The organic phase was separated and washed with water and then brine. Each aqueous phase was back extracted with methylene chloride. The two organic phases were combined, dried over sodium sulfate and concentrated in vacuo. The crude material was purified by flash chromatography eluting with 60-100% ethyl acetate/hexanes to give 5-amino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid ethyl ester (2.554 g, 92%).

1. temperatureAfter cooling to room temperature
2. concentrationthe reaction was concentrated
3. customthe residue was partitioned between methylene chloride and water
4. customThe organic phase was separated
5. washwashed with water
6. extractionEach aqueous phase was back extracted with methylene chloride
7. dry with materialdried over sodium sulfate
8. concentrationconcentrated in vacuo
9. customThe crude material was purified by flash chromatography
10. washeluting with 60-100% ethyl acetate/hexanes