HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 10016649, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Amino-1,2-propanediol | HCID 73561 | — |
| Reactant | 1H-Indole-3-carboxylic acid, 2-chloro-1-methyl- | HCID 99522 | — |
| Product | HCID 10016649 | HCID 10016649 | 46% |
Reaction Steps
Similar reaction of 2-chloro-1-methylindole-3-carboxylic acid [XXI] with SOCl2 and 3-aminopropane-1,2-diol gave N-(2,3-dihydroxypropyl)-2-chloro-1-methylindole-3-carboxamide [XXII: R6 =H;, R7 =CH2CH(OH)CH2OH] (46%) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05464861 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-b39ab1795f98458e9f2c6567675aac01 |
| Source note | uspto-grants-1995_11 |