Chlorosulfonic acid → HCID 21482735, compound

HRID 1288318Notes

Reaction equation

HRID 1288318 reaction equation
[NH2:1][C:2]1[C:7]([Br:8])=[CH:6][C:5]([S:9](N)(=[O:11])=[O:10])=[CH:4][C:3]=1[Br:13].[Cl:14]S(O)(=O)=O>>[NH2:1][C:2]1[C:7]([Br:8])=[CH:6][C:5]([S:9]([Cl:14])(=[O:11])=[O:10])=[CH:4][C:3]=1[Br:13]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 30847334-Amino-3,5-dibromobenzenesulfonamide

Product 1

HCID 21482735HCID 21482735, compound

Procedure

A solution of 15 g. of 4-amino-3,5-dibromobenzenesulfonamide in 45 ml. of chlorosulfonic acid is heated on a steam bath at 95° C. for two hours. The reaction mixture is cooled and poured onto 400 ml. of ice/water mixture. The resultant precipitate is filtered, dissolved in methylene chloride, and the methylene chloride solution is dried, filtered and evaporated to dryness, affording 4-amino-3,5-dibromobenzenesulfonylchloride, m.p. 153°-155° C.

Workup

  1. temperatureThe reaction mixture is cooled
  2. additionpoured onto 400 ml
  3. filtrationThe resultant precipitate is filtered
  4. dissolutiondissolved in methylene chloride
  5. dry with materialthe methylene chloride solution is dried
  6. filtrationfiltered
  7. customevaporated to dryness

Sources & evidence

ORD record
ord-739b009008784cd5a0bdef359536c5f6
Source dataset
uspto-grants-1976_10
Patent number
US03987199

Reaction notes

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