HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-methyl-N-[2-nitro-4-(trifluoromethyl)phenyl]propanamide → N-[2-Amino-4-(trifluoromethyl)phenyl]-2-methylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-methyl-N-[2-nitro-4-(trifluoromethyl)phenyl]propanamide | HCID 3957912 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[2-Amino-4-(trifluoromethyl)phenyl]-2-methylpropanamide | HCID 16774420 | — |
Reaction Steps
Shake 85 g. of 2'-nitro-4'-trifluoromethylisobutyranilide in 1.0 liter of ethanol containing 3.0 g. of 5% palladium on charcoal in a parr shaker under approximately 50 lbs. per square inch hydrogen pressure for twenty-four hours. Filter, remove the ethanol and recrystallize from a dichloromethane-chloroform-hexane mixture, obtaining the product of this step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03987182 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-0f249124da3a4f41b82e5e36446a9729 |
| Source note | uspto-grants-1976_10 |