HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1288322Generated: November 2, 2026
1-Methyl-2-(propan-2-yl)-6-(trifluoromethyl)-1H-benzimidazole → 1-Methyl-5-nitro-2-(propan-2-yl)-6-(trifluoromethyl)-1H-benzimidazole
https://huagongshe.com/reaction/1288322
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Methyl-2-(propan-2-yl)-6-(trifluoromethyl)-1H-benzimidazole | HCID 21504702 | — |
| Reactant | HCID 21504703 | HCID 21504703 | — |
| Reactant | HCID 21504704 | HCID 21504704 | — |
| Reactant | HCID 21504707 | HCID 21504707 | — |
| Reactant | HCID 21504710 | HCID 21504710 | — |
| Reactant | HCID 21504713 | HCID 21504713 | — |
| Reactant | HCID 21504714 | HCID 21504714 | — |
| Reactant | HCID 21504716 | HCID 21504716 | — |
| Reactant | HCID 21504718 | HCID 21504718 | — |
| Reactant | HCID 21504723 | HCID 21504723 | — |
| Product | 1-Methyl-5-nitro-2-(propan-2-yl)-6-(trifluoromethyl)-1H-benzimidazole | HCID 21504715 | — |
Reaction Steps
In a similar manner by substituting for the 2-isopropyl-1-methyl-6-trifluoromethylbenzimidazole reactant of this example an equivalent quantity of: 2-isovaleryl-1-butyl-6-trifluoromethylbenzimidazole, 2-cyclobutyl-1-methyl-6-difluoromethylbenzimidazole, 2-cyclopropyl-1-ethyl-6-pentafluorothylbenzimidazole, 2-isopropyl-1-hexyl-4,6-ditrifluoromethylbenzimidazole, 2-cyclopropyl-1-ethyl-6-fluorobenzimidazole, 2-isobutyl-1-methyl-6-bromobenzimidazole, there is produced: 2-isovaleryl-1-butyl-5-nitro-6-trifluoromethylbenzimidazole, 2-cyclobutyl-1-methyl-5-nitro-6-difluoromethylbenzimidazole, 2-cyclopropyl-1-ethyl-5-nitro-6-pentafluoroethylbenzimidazole, 2-isopropyl-1-hexyl-5-nitro-6-trifluoromethylbenzimidazole, and 2-isobutyl-1-methyl-5-nitro-6-bromobenzimidazole, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03987182 |
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| Source dataset | uspto-grants-1976_10 |
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| ORD ID | ord-c95f4a483fc144568ebb1b5603b4106e |
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| Source note | uspto-grants-1976_10 |
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