反应详情

To a stirred, ice cold solution of 4-(2-tetrahydropyranyloxy)nonylamine (7.29 g., 0.03 mole) in pyridine (40 ml.) is added acetic anhydride (3.06 g., 0.03 mole) at such a rate as to maintain the reaction temperature at 5°-10°C. The reaction is then allowed to stand at room temperature for 6 hours, poured into ice water (200 ml.) and extracted with ether (2 × 100 ml.). The ether is extracted with ice cold 5% hydrochloric acid (2 × 20 ml.), washed with brine (2 × 25 ml.), then dried over sodium sulfate. Evaporation in vacuo affords the subject compound as a pale yellow oil.

1. temperatureto maintain the reaction temperature at 5°-10°C
2. extractionextracted with ether (2 × 100 ml.)
3. extractionThe ether is extracted with ice cold 5% hydrochloric acid (2 × 20 ml.)
4. washwashed with brine (2 × 25 ml.)
5. dry with materialdried over sodium sulfate
6. customEvaporation in vacuo