Ethyl 7-bromoheptanoate → Ethyl 7-{acetyl[4-(acetyloxy)nonyl]amino}heptanoate

Participants

Reaction Steps

The preparation of this compound is accomplished by essentially the same method as described in Example 1, Step A, except that the N-[4-(2-tetrahydropyranyloxy)nonyl]-acetamide of Example 1, Step A is replaced by an equimolar quantity of ethyl 7-acetamidoheptanoate and the ethyl 7-bromoheptanoate is replaced by an equimolar quantity of 1-chloro-4-acetoxynonane (Example A, Step 4). Purification of the product by column chromatography on silica gel gives ethyl 7-[N-(4-acetoxynonyl)acetamido]heptanoate.

Provenance & Evidence