Ethyl 7-bromoheptanoate → ethyl 7-[N-(4-acetoxynonyl)-acrylamido]heptanoate

Participants

Reaction Steps

The synthesis of this compound is carried out as described in Exanple 1 except that, in Step A, the ethyl 7-bromoheptanoate is replaced by an equimolar amount of methyl 7-bromo-2-methylheptanoate (Example L, Step 4). The product of Step A is methyl 7-{N-[4-(2-tetrahydropyranyloxy)nonyl]acetamido}-2-methylheptanoate. The subsequent step yields 7-[N-(4-hydroxynonyl)acetamido]-2-methylheptanoic acid (B).

Provenance & Evidence