Ethyl 7-bromoheptanoate → ethyl 7-[N-(4-acetoxynonyl)-acrylamido]heptanoate

Participants

Reaction Steps

The synthesis of this compound is carried out as described in Example 1 except that, in Step A, the ethyl 7-bromoheptanoate is replaced by an equimolar amount of methyl 3,3-dimethyl-7-iodoheptanoate. The product of Step A is methyl 7-{N-[4-(2-tetrahydropyranyloxy)nonyl]-acetamido}-3,3-dimethylheptanoate. The subsequent step yields 7- [N-(4-hydroxynonyl)acetamido]-3,3-dimethylheptanoic acid (B).

Provenance & Evidence