1-Chloro-4-acetoxynonane → 7-[N-(4(R)-hydroxy-2-nonynyl)acetamido]heptanoic acid

Participants

Reaction Steps

The synthesis of this compound is carried out as described in Example 2 except that, in Step B, the 1-chloro-4-acetoxynonane is replaced by an equimolar amount of 1-chloro-4-acetoxy-5,5-dimethylnonane (Example G, Step 3). The product in Step B is ethyl 7-[N-(4-acetoxy-5,5-dimethylnonyl)acetamido]heptanoate. The subsequent step yields 7-[N-(4-hydroxy-5,5-dimethylnonyl)acetamido]-heptanoic acid (C).

Provenance & Evidence