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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1288412Generated: October 25, 2026

2-Aminophenol → 2-p-Tolylbenzoxazole

https://huagongshe.com/reaction/1288412

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-AminophenolHCID 5801—
ReactantP-Toluic AcidHCID 7470—
ReactantBenzoxazoleHCID 9228—
Product2-p-TolylbenzoxazoleHCID 70039—

Reaction Steps

Preparation of the above benzoxazole reactant is as follows: o-aminophenol is reacted with p-toluic acid to yield 2-(p-tolyl)benzoxazole; this intermediate is then brominated with N-bromosuccinimide to obtain 2-4-bromomethylphenyl)-benzoxazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03988295
Source datasetuspto-grants-1976_10
ORD IDord-f8d332b913374a5a9a11e20767997fbe
Source noteuspto-grants-1976_10