HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropenyl acetate → 2-Acetyl-8-amino-7-chloro-1,2,3,4-tetrahydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropenyl acetate | HCID 7916 | — |
| Reactant | 8-Amino-7-chloro-1,2,3,4-tetrahydroisoquinoline | HCID 21393823 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Acetyl-8-amino-7-chloro-1,2,3,4-tetrahydroisoquinoline | HCID 20523214 | — |
Reaction Steps
8-Amino-7-chloro-1,2,3,4-tetrahydroisoquinoline, prepared as in Example 12, is treated with one molar equivalent of isopropenyl acetate in refluxing ethyl acetate for 16 hours. The solvent is evaporated and the residue crystallized from benzene to yield 2-acetyl-8-amino-7-chloro-1,2,3,4-tetrahydroisoquinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03988339 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-4c610062b31c45648b73fcaecd3ceab1 |
| Source note | uspto-grants-1976_10 |