HCID 21393838, compound → HCID 20523201, compound

HRID 1288472Notes

Reaction equation

HRID 1288472 reaction equation
[N+:1]([C:4]1[C:13]([C:14]([F:17])([F:16])[F:15])=[C:12]2[C:7]([CH:8]=[CH:9][N:10]=[CH:11]2)=[CH:6][CH:5]=1)([O-])=O>[Zn].C(O)(=O)C>[NH2:1][C:4]1[C:13]([C:14]([F:17])([F:15])[F:16])=[C:12]2[C:7]([CH:8]=[CH:9][N:10]=[CH:11]2)=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 21393838HCID 21393838, compound

Product 1

HCID 20523201HCID 20523201, compound

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 176Acetic AcidSolvent

Procedure

Reducing the 7-nitro group of 7-nitro-8-trifluoromethylisoquinoline with zinc and acetic acid by the procedure of Example 17 gives 7-amino-8-trifluoromethylisoquinoline. Hydrogenating by the procedure of Example 9 gives 7-amino-8-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline.

Sources & evidence

ORD record
ord-99ed1f1403c6431d8f5f01a7d99a88aa
Source dataset
uspto-grants-1976_10
Patent number
US03988339

Reaction notes

Loading…