HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 7,8-Dichloro-2-ethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Diboron | HCID 6328200 | — |
| Reactant | 1-(7,8-Dichloro-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one | HCID 12595100 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7,8-Dichloro-2-ethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride | HCID 21393876 | — |
Reaction Steps
2-Acetyl-7,8-dichloro-1,2,3,4-tetrahydroisoquinoline is treated with excess diborane in tetrahydrofuran and refluxed for 16 hours. Methanol is added to destroy excess diborane and the solvent is removed in vacuo. The residue is dissolved in ether, treated with hydrogen chloride and filtered to give 7,8-dichloro-2-ethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03988339 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-63308174426e4e1cbcb81f9b6801a2e7 |
| Source note | uspto-grants-1976_10 |