反应详情

Lithium aluminum hydride, 0.61 g. (0.016 mole), is weighed under nitrogen, transferred to a dry, nitrogen-flushed reaction flask and suspended in 50 ml. of absolute ether. The mixture is stirred at reflux for 30 minutes, then cooled to room temperature and a solution of 2.4 g. (0.008 mole) of 2-(4-bromophenethyl)-phenylacetonitrile in 30 ml. of absolute ether is added dropwise. After 16 hours at reflux, the cooled mixture is hydrolyzed by the successive dropwise addition of 0.7 ml. of water, 0.7 ml. of 20% aqueous sodium hydroxide, and 1.5 ml. of water. The ethereal layer is separated and stirred with 18 ml. of 3N hydrochloric acid. The hydrochloride salt of the product separates, m.p. 148°-153° C. (cloudy melt). Repeated recrystallizations from absolute ethanol-ether and from water yield purified material, m.p. 148°-150° C. (cloudy melt). The hydrochloride is converted to the base by rendering an aqueous solution strongly alkaline. The oily base is extracted into benzene. Evaporation of the washed and dried benzene extract under reduced pressure leaves the product as the residual oil. The base may be converted to the hydrogen maleate salt by treating a solution in methanol with a slight excess of maleic acid. Dilution with absolute ether precipitates the hydrogen maleate in white crystals, m.p. 158°-160° C.

1. customflushed
2. customreaction flask
3. temperatureat reflux for 30 minutes
4. temperatureAfter 16 hours at reflux
5. additionthe cooled mixture is hydrolyzed by the successive dropwise addition of 0.7 ml
6. customThe ethereal layer is separated
7. stirringstirred with 18 ml
8. customrecrystallizations from absolute ethanol-ether
9. customfrom water yield
10. custompurified material, m.p. 148°-150° C. (cloudy melt)
11. extractionThe oily base is extracted into benzene
12. customEvaporation of the
13. washwashed
14. extractiondried benzene extract under reduced pressure
15. customleaves the product as the residual oil
16. customDilution with absolute ether precipitates the hydrogen maleate in white crystals, m.p. 158°-160° C.