反应详情

To a mixture of 4.50 g. of 1-(β-napthylmethyl)piperazine(as prepared in Example 7), 2.5 g. of 2-chloro-5-hydroxypyrimidine in 30 ml. of dimethylformamide is added 2.0 g. of sodium bicarbonate and the mixture is refluxed for six hours. The mixture is cooled and filtered and the filtrate concentrated to a small volume in vacuo. The concentrate is diluted with 100 ml. of water and the insoluble material is washed with water and hexane to yield 1-(β-napthylmethyl)-4-(5-hydroxy-2-pyrimidinyl)piperazine.

1. additionTo a mixture of 4.50 g
2. temperatureThe mixture is cooled
3. filtrationfiltered
4. concentrationthe filtrate concentrated to a small volume in vacuo
5. additionThe concentrate is diluted with 100 ml
6. washof water and the insoluble material is washed with water and hexane