HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 6-{[4-(Pyridin-2-yl)piperazin-1-yl]methyl}naphthalen-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 1-[(5-Methoxynaphthalen-2-yl)methyl]-4-(pyridin-2-yl)piperazine | HCID 21502910 | — |
| Product | 6-{[4-(Pyridin-2-yl)piperazin-1-yl]methyl}naphthalen-1-ol | HCID 21502907 | — |
Reaction Steps
A solution of 3.4 g. of 1-(5-methoxy-β-naphthylmethyl)-4-(2-pyridyl)piperazine in 100 ml. of 48% hydrogen bromide is refluxed for 3 hours. The mixture is cooled, concentrated and treated with sodium carbonate. The mixture is extracted with chloroform and the chloroform extractions are dried to yield 1-(5-hydroxy-β-naphtylmethyl)-4-(2-pyridyl)piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03988457 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-06a78da21a1248aa942cd52eed35122b |
| Source note | uspto-grants-1976_10 |