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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1288582Generated: October 26, 2026

(1,1'-Biphenyl)-2-carboxaldehyde → 2,6-Diamino-4-(biphenyl-2-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

https://huagongshe.com/reaction/1288582

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1,1'-Biphenyl)-2-carboxaldehydeHCID 121052—
ReactantCarbamimidoyl-acetic acid ethyl esterHCID 4599837—
SolventEthanolHCID 702—
Product2,6-Diamino-4-(biphenyl-2-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl esterHCID 7063164433%

Reaction Steps

Upon heating a solution of 9.1 g biphenyl-2-aldehyde and 13.0 g amidinoacetic acid ethyl ester in 200 ml ethanol for 2 hours, 2,6-diamino-4-(biphenyl-2-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of m.p. 215° (ethanol) is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03988458
Source datasetuspto-grants-1976_10
ORD IDord-6244a8b7c6ef41d88bf6902353321547
Source noteuspto-grants-1976_10