HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl benzylidenecyanoacetate → 2,6-Diamino-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl benzylidenecyanoacetate | HCID 74845 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | Amidinoacetic acid isopropyl ester | HCID 12391080 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,6-Diamino-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester | HCID 70631841 | 54% |
Reaction Steps
Upon heating a solution of 10.1 g benzylidenecyanoacetic acid ethyl ester, 7.2 g amidinoacetic acid isopropyl ester and 0.6 g sodium ethylate in 150 ml ethanol for 4 hours, 2,6-diamino-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester of m.p. 170° is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03988458 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-e2d588188df1477282bafd3023e9d9a4 |
| Source note | uspto-grants-1976_10 |