HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 178492455, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 178492456 | HCID 178492456 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 178492455 | HCID 178492455 | — |
Reaction Steps
400 mg of sodium cyanoborohydride, 0.5 ml of 35% aqueous formaldehyde solution and a little sodium sulphate are added to a solution of 434 mg of 4-de-dimethylamino-4-amino-7-methoxy-6-thiatetracycline (obtained in accordance with Example 1) in 80 ml of methanol and the mixture is stirred for 30 minutes at 20°. Chloroform is then added, followed by washing with dilute hydrochloric acid, drying and evaporation to give 7-methoxy-6-thiatetracycline, m.p. 225°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03988468 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-52dcc8683c3449758282dbb72b20b735 |
| Source note | uspto-grants-1976_10 |