Sodium Hydroxide → HCID 70259933, compound

HRID 1288657Notes

Reaction equation

HRID 1288657 reaction equation
C([O:3][C:4](=[O:20])[C@H:5]([CH3:19])[N:6]([C:11]1[CH:16]=[CH:15][C:14]([S:17][CH3:18])=[CH:13][CH:12]=1)[CH2:7][CH2:8][CH2:9][CH3:10])C.[OH-].[Na+:22]>CO.O>[Na+:22].[CH3:18][S:17][C:14]1[CH:13]=[CH:12][C:11]([N:6]([CH2:7][CH2:8][CH2:9][CH3:10])[C@H:5]([C:4]([O-:20])=[O:3])[CH3:19])=[CH:16][CH:15]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 54253050HCID 54253050, compound

Product 1

HCID 70259933HCID 70259933, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent2×

Procedure

N-(4-Methylthiophenyl)-N-(n-butyl)alanine ethyl ester (3.0 g, 10.1 mmol) was dissolved in 50 mL methanol and 5 mL of water was added. Sodium hydroxide (0.41 g, 10.1 mmol) was dissolved in a minimum amount of water, and added to the aqueous methanol solution. The mixture was stirred 18 h at room temperature, and then the solvent was removed at reduced pressure. The resulting white solid was used without purification.

Workup

  1. customthe solvent was removed at reduced pressure
  2. customThe resulting white solid was used without purification

Sources & evidence

ORD record
ord-18c54a7989434ae3ba4c0b65e21fac06
Source dataset
uspto-grants-1998_05
Patent number
US05747235

Reaction notes

Loading…