HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → Methylglyoxal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 1-Chloro-4-(2,2,2-trichloro-1-(4-chlorophenyl)ethyl)benzene | HCID 3036 | — |
| Reactant | Glutathione | HCID 124886 | — |
| Reactant | 4-Maleylacetoacetic acid | HCID 5280393 | — |
| Product | Methylglyoxal | HCID 880 | — |
| Product | Glutathione | HCID 124886 | — |
Reaction Steps
Glutathione functions as a co-enzyme for formaldehyde dehydrogenase, maleylacetoacetate isomerase, glyoxalase, prostaglandin endoperoxidase isomerases, and dichlorodiphenyltrichloroethane dehydrochlorinase and similar enzymes. In the glyoxalase reaction, the hemimercaptal formed nonenzymatically by reaction of methylglyoxal and glutathione (GSH) is converted by glyoxalase I to S-lactyl-Glutathione, which is split by glyoxalase II to D-lactate and Glutathione. In the formaldehyde dehydrogenase reaction, S-formyl Glutathione is formed (Glutathione+HCHO+NAD+) and hydrolyzed to formate and Glutathione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05747329 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-20f240749d8c4433b23b4769c315dad3 |
| Source note | uspto-grants-1998_05 |