Pyridinium chloride → HCID 15334439, compound

HRID 1288673Notes

Reaction equation

HRID 1288673 reaction equation
[Cl:1][C:2]1[C:3]([C:12]2[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[C:14]([O:20]C)[CH:13]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Cl.N1C=CC=CC=1>O>[Cl:1][C:2]1[C:3]([C:12]2[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[C:14]([OH:20])[CH:13]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18924596HCID 18924596, compound

Product 1

HCID 15334439HCID 15334439, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5.0 g of 3-chloro-2-(4-cyano-3-methoxyphenyl)-5-trifluoromethylpyridine and 5.5 g of pyridine hydrochloride were stirred for 2 hours at 200° C. After cooling, the reaction mixture was thoroughly stirred with 100 ml of water. The solid portion was then separated off and purified by means of column chromatography on silica gel (cyclohexane/methyl tert-butyl ether (2:1) as eluent). Yield: 3.4 g (71%) of white crystals having a melting point of 155°-157° C.

Workup

  1. temperatureAfter cooling
  2. customThe solid portion was then separated off
  3. custompurified by means of column chromatography on silica gel (cyclohexane/methyl tert-butyl ether (2:1) as eluent)

Sources & evidence

ORD record
ord-a9704b77a9ca4095a3855130e14e6d66
Source dataset
uspto-grants-1998_05
Patent number
US05747422

Reaction notes

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