Water → 2,3-Dichloro-4-trifluoromethoxybenzoic acid

HRID 1288722노트

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HRID 1288722 반응식
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([O:12][C:13]([F:16])([F:15])[F:14])[CH:8]=[CH:7][C:3]=1[C:4](F)=[O:5].[OH2:17]>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([O:12][C:13]([F:16])([F:15])[F:14])[CH:8]=[CH:7][C:3]=1[C:4]([OH:17])=[O:5]

참가 물질

3

반응물 2

HCID 962WaterHCID 539612062,3-Dichloro-4-trifluoromethoxybenzoyl fluoride

생성물 1

HCID 543779072,3-Dichloro-4-trifluoromethoxybenzoic acid

실험 절차

A suspension of crude 2,3-dichloro-4-trifluoromethoxybenzoyl fluoride (2 g, containing mixed antimony halides) in water was stirred vigorously for 24 hours. The mixture was extracted with dichloromethane and filtered. The organic layer was washed with hydrochloric acid (2M), aqueous sodium chloride solution and extracted into sodium carbonate solution (2M). The aqueous extract was acidified to pH 1 and the solid was filtered off and washed with water to give 2,3-dichloro-4-trifluoromethoxybenzoic acid (0.6 g) as a white solid mp 123°-126° C.

후처리

  1. extractionThe mixture was extracted with dichloromethane
  2. filtrationfiltered
  3. washThe organic layer was washed with hydrochloric acid (2M), aqueous sodium chloride solution
  4. extractionextracted into sodium carbonate solution (2M)
  5. extractionThe aqueous extract
  6. filtrationthe solid was filtered off
  7. washwashed with water

출처 및 근거

ORD 기록
ord-20f8929b3f054551a66837e507bfa763
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05747424

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