p-Toluenesulfonic acid → HCID 53897219, compound

Participants

Reaction Steps

A solution of t-butyl 3-cyclopropyl-2-(2-methoxy-4-methylsulphenylbenzoyl)-3-oxopropionate (35.1 g) and 4-toluenesulphonic acid (1.2 g) in toluene was stirred and heated at reflux for 8 hours. After cooling, it was washed with water, dried (anhydrous magnesium sulphate) and filtered. The filtrate was evaporated to dryness to give 3-cyclopropyl-1-(2-methoxy-4-methylsulphenylphenyl)-propan-1,3-dione (25.8 g) as a red solid, NMR (CDCl3); 0.7-1.2 (m,4H), 1.4-2.0 (m,1H), 2.4(s,3H), 3.75 (s,3H), 6.4(s,1H), 6.6(s,1H), 6.65 (d,1H) and 7.65 (d,1H).

Provenance & Evidence