Ethylene Glycol → HCID 18924616, compound

Participants

Reaction Steps

2-Chloro-6-fluorobenzaldehyde (100 g), ethylene glycol (192 g) and p-toluenesulphonic acid (17 g) were dissolved in toluene and heated under reflux for four days using a Dean and Stark adapter to collect the water. After cooling the mixture was washed with water, dried (anhydrous magnesium sulphate) and filtered. The filtrate was evaporated to dryness yielding 2-(2-chloro-6-fluorophenyl)-1,3-dioxolane (149 g) as an orange oil , NMR (CDCl3) 4.09(s 4,2H), 4.3(m, 2H), 6.35(s,1H), 7. 2(m,3H).

Provenance & Evidence