Sodium Cyanide → HCID 12241882, compound

HRID 1288798Notes

Reaction equation

HRID 1288798 reaction equation
Cl[CH2:2][C:3]([CH3:11])([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:4].[C-:12]#[N:13].[Na+]>CS(C)=O>[CH3:4][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)([CH3:11])[CH2:2][C:12]#[N:13]

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 68191Neophyl chloride

Product 1

HCID 12241882HCID 12241882, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 1-chloro-2-methyl-2-phenylpropane (150 g, 0.889 mol) and NaCN (54.46 g) in DMSO (250 mL) was heated at 100 ° C for 3 weeks. The resulting solution was concentrated to half the initial volume, H2O (400 mL) was added and it was extracted with Et2O (3x). The combined organic extractes were dried and concentrated to a crude product (115.1 g), which was directly used in the next step as obtained.

Workup

  1. concentrationThe resulting solution was concentrated to half the initial volume, H2O (400 mL)
  2. additionwas added
  3. extractionit was extracted with Et2O (3x)
  4. customThe combined organic extractes were dried
  5. concentrationconcentrated to a crude product (115.1 g), which
  6. customas obtained

Sources & evidence

ORD record
ord-65e56d1269d84383ba15f0577810cc1e
Source dataset
uspto-grants-1998_05
Patent number
US05747477

Reaction notes

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