Benzyl (2S)-4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-2-[(2-methyl-2-propanyl)carbamoyl]-1-piperazinecarboxylate → HCID 10739024, compound

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Reaction Steps

A solution of (S)-1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(benzyloxy)carbonyl]-3-(1,1-dimethylethylamino)carbonyl piperazine (1.11 g, 2.124 mmol) and 10% Pd-C (111 mg, 10 weight %) in dry EtOH (8 mL) was evacuated under high vacuum and purged to a H2 balloon (14 h). The mixture was filtered through Celite (30 mm×30 mm), the filter cake washed with EtOH and concentrated in vacuo. PCTLC (SiO2, 4 mm, 0-10% CH3OH/CH2 Cl2) provided the title compound.

Provenance & Evidence