2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 53763865, compound

Participants

Reaction Steps

A solution of 4-amino-2-chloro-6,7-dimethoxyquinazoline (94.4 mg, 0.3939 mmol) and (R)-4-[(1,1-dimethylethoxy)carbonyl]-3-(1,1-dimethylethylamino) carbonyl piperazine (see Askin, D. et al., Tetrahedron Letters 1994, 35, 673-676) (112.4 mg, 0.3939 mol) in 2-propanol (1 mL) was heated at 90° C. (24 h). The solvent was removed in vacuo and the residue subjected to PCTLC (SiO2, 2 mm, 0-10% MeOH/CH2Cl2) which afforded ((R)-1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(1,1-dimethylethoxy)carbonyl]-3-(1,1-dimethylethylamino)carbonyl piperazine.

Provenance & Evidence