Diisopropylethylamine → HCID 54264319, compound

Participants

Reaction Steps

A solution of 4-amino-2-chloro-6,7-dimethoxyquinazoline (92.8 mg, 0.387 mmol), diisopropylethyl amine (50 mg, 0.387), and (S)-proline methyl ester (50.0 mg, 0.387 mol) in 2-propanol (1 mL) was heated at 90° C. (24 h). The solvent was removed in vacuo and the residue subjected to preparative HPLC Water Delta Prep 4000 (C18, isocratic 50% CH3CN [0.1% TFA]-50% H2O [0.1% TFA]) to afford (S)-1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-2-carboxymethyl pyrrolidine and (S)-1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-2-carboxyisopropyl pyrrolidine. For (S)-1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-2-carboxymethyl pyrrolidine:

Provenance & Evidence