HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-(4-Nitrobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one → 3-(4-Aminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-(4-Nitrobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one | HCID 9801942 | — |
| Katalysator | Nickel | HCID 935 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 3-(4-Aminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one | HCID 10134689 | — |
Reaktionsschritte
A solution of 3.9 g of 3-(4-nitrobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one in 40 ml of tetrahydrofuran is hydrogenated in the presence of Raney nickel. The catalyst is filtered off and the solution is concentrated. Recrystallization gives 3-(4-aminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one, m.p. 105°.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05747489 |
| Quelldatensatz | uspto-grants-1998_05 |
| ORD ID | ord-2cf32e2ab8c54e4db535ce4e272c9586 |
| Quellennotiz | uspto-grants-1998_05 |