HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thioglycolic Acid → {2-[4-(3-Ethynyl-phenylamino)-7-(2-methoxy-ethoxy)-quinazolin-6-yloxy]-ethylsulfanyl}-acetic acid ammonium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thioglycolic Acid | HCID 1133 | — |
| Reactant | 6-O-Desmethoxyethyl-6-O-chloroethyl Erlotinib Hydrochloride | HCID 18925062 | — |
| Product | {2-[4-(3-Ethynyl-phenylamino)-7-(2-methoxy-ethoxy)-quinazolin-6-yloxy]-ethylsulfanyl}-acetic acid ammonium salt | HCID 131720631 | — |
Reaction Steps
This product was prepared from the title product of Example 30 and mercaptoacetic acid at 22° C. over 10 days according to the method outlined in Example 45. (16%; M.P. 98°-113° C. (dec); LC-MS 454 (MH+); anal. RP-HPLC 3.24 min.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05747498 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-87877f2dc4804aa483120ce1a3452074 |
| Source note | uspto-grants-1998_05 |