3-Chlorobenzo(b)thiophene-2-carbonyl chloride → HCID 22105884, compound

HRID 1288980Notes

Reaction equation

HRID 1288980 reaction equation
[Cl:1][C:2]1[C:3]2[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=2[S:5][C:6]=1[C:7](Cl)=[O:8].[NH2:14][C:15]1[CH:37]=[CH:36][C:18]([C:19]([N:21]2[CH2:27][C:26]3[CH:28]=[CH:29][CH:30]=[CH:31][C:25]=3[CH2:24][C:23]3[CH:32]=[CH:33][CH:34]=[CH:35][C:22]2=3)=[O:20])=[CH:17][CH:16]=1>>[CH:32]1[C:23]2[CH2:24][C:25]3[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=3[CH2:27][N:21]([C:19]([C:18]3[CH:17]=[CH:16][C:15]([NH:14][C:7]([C:6]4[S:5][C:4]5[CH:10]=[CH:11][CH:12]=[CH:13][C:3]=5[C:2]=4[Cl:1])=[O:8])=[CH:37][CH:36]=3)=[O:20])[C:22]=2[CH:35]=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 5198983-Chlorobenzo(b)thiophene-2-carbonyl chlorideHCID 154104675-(4-Aminobenzoyl)-6,11-dihydro-5H-dibenz[b,e]azepine

Product 1

HCID 22105884HCID 22105884, compound

Procedure

As described for Example 9, 3-chlorobenzo[b]-thiophene-2-carbonyl chloride is reacted with 5-(4-aminobenzoyl)-6,11-dihydro-5H-dibenz[b,e]azepine to give the product. Recrystallization from dichloromethane-hexane gives crystals, m.p. 252°-254° C.

Workup

  1. customto give the product
  2. customRecrystallization from dichloromethane-hexane
  3. customgives crystals, m.p. 252°-254° C.

Sources & evidence

ORD record
ord-248453cdb6164a26a3115048d86d645e
Source dataset
uspto-grants-1998_05
Patent number
US05747487

Reaction notes

Loading…