Phosphorus oxychloride → HCID 15293562, compound

Participants

Reaction Steps

15.3 g of the product of step (v) and 12.4 g POCl3 in 250 ml acetonitrile are stirred for 5 hrs. under reflux. The reaction mixture is concentrated, the residue taken up in ethyl acetate and extracted with Na2CO3 solution and brine. The organic phase is dried over Na2SO4, filtered and evaporated and the residue purified chromatographically on silica gel (e 0.04-0.63 mm) to yield the title compound as an oil.

Provenance & Evidence