참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | N-Methoxy-N,4-dimethyloxazole-5-carboxamide | HCID 18925369 | — |
| 반응물 | HCID 178506676 | HCID 178506676 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (4-Methyloxazol-5-yl)(phenyl)methanone | HCID 53876795 | — |
반응 단계
Phenyllithium (1.8M solution in cyclohexane-diethylether, 11.7ml) in dry tetrahydrofuran was stirred and cooled to -70° C. under an atmosphere of dry nitrogen and N-methoxy-N-methyl-4-methyl-5-oxazolecarboxamide (3.0g) in dry tetrahydrofuran was added dropwise. After 30 minutes the mixture was allowed to warm to room temperature. Ethanol (5ml) was added followed by saturated aqueous sodium chloride. The mixture was extracted with dichloromethane and the material thus obtained was purified by flash chromatography to give the title compound. M.p. 84-86° C. 1H Nmr (CDCl3) 2.59 (3H, s), 7.5-7.68 (3H, m) and 7.96-8.06) (3H, m) ppm.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05747515 |
|---|
| 출처 데이터셋 | uspto-grants-1998_05 |
|---|
| ORD ID | ord-3cabfcf4a5cc4b649c69305f11bd9a8b |
|---|
| 출처 메모 | uspto-grants-1998_05 |
|---|
